Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway
Background Doxorubicin (DOX) is a broad-spectrum anti-tumor drug that has been
associated with cardiotoxicity. Plant extracts have been shown to confer protection against
DOX-induced cardiotoxicity. Apocynum venetum L. belongs to the Apocynaceae family.
Flavonoid extracted from Apocynum venetum L. possess various biological effects, such as
lowering blood pressure levels, sedation, diuresis, anti-aging, and improving immunity.
Purpose This study investigated the mechanism by which dry leaf extract of Apocynum …
associated with cardiotoxicity. Plant extracts have been shown to confer protection against
DOX-induced cardiotoxicity. Apocynum venetum L. belongs to the Apocynaceae family.
Flavonoid extracted from Apocynum venetum L. possess various biological effects, such as
lowering blood pressure levels, sedation, diuresis, anti-aging, and improving immunity.
Purpose This study investigated the mechanism by which dry leaf extract of Apocynum …
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