[HTML][HTML] Apoptosis of cultured granulosa-lutein cells is reduced by insulin-like growth factor I and may correlate with embryo fragmentation and pregnancy rate
E Bencomo, R Pérez, MF Arteaga, E Acosta, O Peña… - Fertility and sterility, 2006 - Elsevier
OBJECTIVE: To correlate apoptosis of cultured human granulosa-lutein cells (GL cells) with
the outcome of IVF (embryo fragmentation and pregnancy rate) and to study the effect of
insulin and insulin-like growth factor I (IGF-I) on apoptosis. DESIGN: In vitro assays.
SETTING: University laboratory and private IVF center. PATIENT (S): Eighty-one women
undergoing IVF. INTERVENTION (S): Purified human GL cells from pooled follicles were
cultured for 48 hours in serum-free media with or without insulin and IGF-I. Cumulus cells …
the outcome of IVF (embryo fragmentation and pregnancy rate) and to study the effect of
insulin and insulin-like growth factor I (IGF-I) on apoptosis. DESIGN: In vitro assays.
SETTING: University laboratory and private IVF center. PATIENT (S): Eighty-one women
undergoing IVF. INTERVENTION (S): Purified human GL cells from pooled follicles were
cultured for 48 hours in serum-free media with or without insulin and IGF-I. Cumulus cells …
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