… apple flavonoid fraction (AF4) against various carcinogen-induced toxicity in normal human
bronchial epithelial cells and its mechanism of DNA damage response and repair processes…

… DNA damage in human bronchial epithelial cells (BEAS-2B) with and without the combination
of apple peel flavonoid … to stop the cell cycle and trigger DDR mechanisms in the cell [22]. …

… NNKAc)-induced ROS and DNA damage in human bronchial … suppressed the NNKAc-induced
ROS and DNA damage. … Luteolin, chrysin, cyanidin, and non-flavonoid compound …

… precursor of NKK, in human lung epithelial BEAS-2B cells in vitro. A … carcinogen-induced
DNA damage in normal lung epithelial … of polyphenols, including flavonoids and phenolic acids (…

… chemical carcinogen-induced toxicity in human lung epithelial cells … of flavonoids in promoting
ATR-dependant DNA damage … protein and suppressing NNKOAc-induced oxidative stress …

… with haskap extracts, Q3G, and C3G, significantly suppressed the NNKand NNKOAc-induced
DNA … Figure 4 The mechanism of NNK-induced carcinogenesis in lung epithelial cells. …

… Plant-food flavonoids alone or in combinations with … for use in this carcinogen-induced DNA
damage cell model [13,21]… antioxidant formulation (AOX1), apple flavonoids (AF4), quercetin, …

… association between lung cancer risk and regular consumption of onions, apple (main dietary
source of flavonoid quercetin) … Oxidative DNA damage is the central process causing lung …

… in normal human bronchial epithelial cells. The study demonstrated that apple flavonoids
could … generation and protect against carcinogen-induced oxidative DNA damage and facilitate …

… BCL-2 associated X protein BEAS-2B Human bronchial epithelial cells … pretreated with
apple flavonoids and exposed to oxidative stress using known carcinogens, NNK, NNKOAc, …