Aim To assess whether the application of a topical vapocoolant spray immediately prior to
initial intradermal anaesthetic injection during ultrasound-guided breast biopsy decreases
pain at the site of the initial injection. Materials and methods In this institutional review board-
approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant study, 50
women aged 49.1±1.6 years (mean±standard error) were recruited and provided written
informed consent. Participants served as their own controls and were blinded as to whether …