Aquasomes are round particles made up of calcium phosphate or ceramic diamond coated with a polyhydroxyloligomeric film and perform as nanoparticulate carrier system but despite of being simple nanoparticle these are three layered self-assembled structures, made up of a solid phase nanocrystalline core coated with oligomeric film on which biochemically active molecules are adsorbed with or without changes. The strong center core gives the structural stability, however the carbohydrate coating provides protection against dehydration and stabilizes the biochemically active molecules. After synthesis of solid center of ceramic and polyhydroxyoligomeric material coating like cellulobiose and trehalose the last stage were drug loading during which the aquasomes act as host particles to non-covalently interact with bio-active moiety via hydrogen and cationic bonding. It facilitates delivery of various protein molecules like liable enzymes and insulin via non covalently adsorption over polysaccharide layer and conforms the stability and remain orally active.