Asparaginase induces selective dose‐and time‐dependent cytotoxicity, apoptosis, and reduction of NFκB expression in oral cancer cells
GÁ Borges, ST Elias, TSD Araujo… - Clinical and …, 2020 - Wiley Online Library
Asparaginase is fundamental to the treatment of haematological malignancies. However,
little has been studied on the effects that asparaginase could exert on solid tumours. Thus,
this study aimed to evaluate the effects of asparaginase on an oral carcinoma cell line. The
cytotoxicity of asparaginase in SCC‐9 (tongue squamous cell carcinoma) and HaCaT
(human keratinocyte) cell lines was evaluated with MTT cell viability assay. The cells were
treated with asparaginase at 0.04, 0.16, 0.63, 1.0, 1.5, 2.5, and 5.0 IU/mL. Dose‐response …
little has been studied on the effects that asparaginase could exert on solid tumours. Thus,
this study aimed to evaluate the effects of asparaginase on an oral carcinoma cell line. The
cytotoxicity of asparaginase in SCC‐9 (tongue squamous cell carcinoma) and HaCaT
(human keratinocyte) cell lines was evaluated with MTT cell viability assay. The cells were
treated with asparaginase at 0.04, 0.16, 0.63, 1.0, 1.5, 2.5, and 5.0 IU/mL. Dose‐response …
Asparaginase induces selective dose-and time-dependent cytotoxicity, apoptosis, and reduction of NFκB expression in oral cancer cells
GÁ Borges, ST Elias, TSD Araujo, PM Souza… - 2020 - deepblue.lib.umich.edu
Asparaginase is fundamental to the treatment of haematological malignancies. However,
little has been studied on the effects that asparaginase could exert on solid tumours. Thus,
this study aimed to evaluate the effects of asparaginase on an oral carcinoma cell line. The
cytotoxicity of asparaginase in SCC-9 (tongue squamous cell carcinoma) and HaCaT
(human keratinocyte) cell lines was evaluated with MTT cell viability assay. The cells were
treated with asparaginase at 0.04, 0.16, 0.63, 1.0, 1.5, 2.5, and 5.0 Â IU/mL. Dose-response …
little has been studied on the effects that asparaginase could exert on solid tumours. Thus,
this study aimed to evaluate the effects of asparaginase on an oral carcinoma cell line. The
cytotoxicity of asparaginase in SCC-9 (tongue squamous cell carcinoma) and HaCaT
(human keratinocyte) cell lines was evaluated with MTT cell viability assay. The cells were
treated with asparaginase at 0.04, 0.16, 0.63, 1.0, 1.5, 2.5, and 5.0 Â IU/mL. Dose-response …
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