Association of apolipoprotein E ɛ4 allele with clinical and multimodal biomarker changes of Alzheimer disease in adults with Down syndrome
Importance Alzheimer disease (AD) is the leading cause of death in individuals with Down
syndrome (DS). Previous studies have suggested that theAPOEɛ4 allele plays a role in the
risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce.
Objective To investigate the association of theAPOEɛ4 allele with clinical and multimodal
biomarkers of AD in adults with DS. Design, Setting, and Participants This dual-center cohort
study recruited adults with DS in Barcelona, Spain, and in Cambridge, UK, between June 1 …
syndrome (DS). Previous studies have suggested that theAPOEɛ4 allele plays a role in the
risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce.
Objective To investigate the association of theAPOEɛ4 allele with clinical and multimodal
biomarkers of AD in adults with DS. Design, Setting, and Participants This dual-center cohort
study recruited adults with DS in Barcelona, Spain, and in Cambridge, UK, between June 1 …
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