Association of fast ripples on intracranial EEG and outcomes after epilepsy surgery
Neurology, 2020•AAN Enterprises
Objective To examine whether fast ripples (FRs) are an accurate marker of the epileptogenic
zone, we analyzed overnight stereo-EEG recordings from 43 patients and hypothesized that
FR resection ratio, maximal FR rate, and FR distribution predict postsurgical seizure
outcome. Methods We detected FRs automatically from an overnight recording edited for
artifacts and visually from a 5-minute period of slow-wave sleep. We examined primarily the
accuracy of removing≥ 50% of total FR events or of channels with FRs to predict …
zone, we analyzed overnight stereo-EEG recordings from 43 patients and hypothesized that
FR resection ratio, maximal FR rate, and FR distribution predict postsurgical seizure
outcome. Methods We detected FRs automatically from an overnight recording edited for
artifacts and visually from a 5-minute period of slow-wave sleep. We examined primarily the
accuracy of removing≥ 50% of total FR events or of channels with FRs to predict …
Objective
To examine whether fast ripples (FRs) are an accurate marker of the epileptogenic zone, we analyzed overnight stereo-EEG recordings from 43 patients and hypothesized that FR resection ratio, maximal FR rate, and FR distribution predict postsurgical seizure outcome.
Methods
We detected FRs automatically from an overnight recording edited for artifacts and visually from a 5-minute period of slow-wave sleep. We examined primarily the accuracy of removing ≥50% of total FR events or of channels with FRs to predict postsurgical seizure outcome (Engel class I = good, classes II–IV = poor) according to the whole-night and 5-minute analysis approaches. Secondarily, we examined the association of low overall FR rates or absence or incomplete resection of 1 dominant FR area with poor outcome.
Results
The accuracy of outcome prediction was highest (81%, 95% confidence interval [CI] 67%–92%) with the use of the FR event resection ratio and whole-night recording (vs 72%, 95% CI 56%–85%, for the visual 5-minute approach). Absence of channels with FR rates >6/min (p = 0.001) and absence or incomplete resection of 1 dominant FR area (p < 0.001) were associated with poor outcome.
Conclusions
FRs are accurate in predicting epilepsy surgery outcome at the individual level when overnight recordings are used. Absence of channels with high FR rates or absence of 1 dominant FR area is a poor prognostic factor that may reflect suboptimal spatial sampling of the epileptogenic zone or multifocality, rather than an inherently low sensitivity of FRs.
Classification of evidence
This study provides Class II evidence that FRs are accurate in predicting epilepsy surgery outcome.
American Academy of Neurology以上显示的是最相近的搜索结果。 查看全部搜索结果