Association of neutrophil-to-lymphocyte ratio with mortality and cardiovascular disease in the Jackson Heart Study and modification by the Duffy antigen variant

S Kim, M Eliot, DC Koestler, WC Wu… - JAMA cardiology, 2018 - jamanetwork.com
Importance The neutrophil-to-lymphocyte ratio (NLR) is associated with mortality and
cardiovascular disease at the time of incident disease, but it is not known whether this is true
in prospective studies. Further, a common genetic variant of African origin associated with a
relative neutropenia, the Duffy antigen variant, is a candidate to modify associations
between NLR and outcomes. Objective To investigate the association between NLR and
mortality and cardiovascular-related outcomes in the Jackson Heart Study (JHS) and …
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