Association of retinal changes with Alzheimer disease neuroimaging biomarkers in cognitively normal individuals
Importance Retinal biomarkers reflecting in vivo brain Alzheimer disease (AD) pathologic
abnormalities could be a useful tool for screening cognitively normal (CN) individuals at the
preclinical stage of AD. Objectives To investigate the association of both functional and
structural alterations of the retina with in vivo AD pathologic abnormalities in CN older adults
and model a screening tool for detection of preclinical AD. Design, Setting, and Participants
This cross-sectional study included a total of 49 CN individuals, and all assessment was …
abnormalities could be a useful tool for screening cognitively normal (CN) individuals at the
preclinical stage of AD. Objectives To investigate the association of both functional and
structural alterations of the retina with in vivo AD pathologic abnormalities in CN older adults
and model a screening tool for detection of preclinical AD. Design, Setting, and Participants
This cross-sectional study included a total of 49 CN individuals, and all assessment was …
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