[HTML][HTML] Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly (ADP-ribose)-dependent pathway in the early response to DNA …
Poly (ADP-ribosyl) ation is a post-translational modification that is instantly stimulated by
DNA strand breaks creating a unique signal for the modulation of protein functions in DNA
repair and cell cycle checkpoint pathways. Here we report that lack of poly (ADP-ribose)
synthesis leads to a compromised response to DNA damage. Deficiency in poly (ADP-
ribosyl) ation metabolism induces profound cellular sensitivity to DNA-damaging agents,
particularly in cells deficient for the protein kinase ataxia telangiectasia mutated (ATM). At …
DNA strand breaks creating a unique signal for the modulation of protein functions in DNA
repair and cell cycle checkpoint pathways. Here we report that lack of poly (ADP-ribose)
synthesis leads to a compromised response to DNA damage. Deficiency in poly (ADP-
ribosyl) ation metabolism induces profound cellular sensitivity to DNA-damaging agents,
particularly in cells deficient for the protein kinase ataxia telangiectasia mutated (ATM). At …
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