Autoantibody profiling of glioma serum samples to identify biomarkers using human proteome arrays
The heterogeneity and poor prognosis associated with gliomas, makes biomarker
identification imperative. Here, we report autoantibody signatures across various grades of
glioma serum samples and sub-categories of glioblastoma multiforme using Human
Proteome chips containing~ 17000 full-length human proteins. The deduced sets of
classifier proteins helped to distinguish Grade II, III and IV samples from the healthy subjects
with 88, 89 and 94% sensitivity and 87, 100 and 73% specificity, respectively. Proteins …
identification imperative. Here, we report autoantibody signatures across various grades of
glioma serum samples and sub-categories of glioblastoma multiforme using Human
Proteome chips containing~ 17000 full-length human proteins. The deduced sets of
classifier proteins helped to distinguish Grade II, III and IV samples from the healthy subjects
with 88, 89 and 94% sensitivity and 87, 100 and 73% specificity, respectively. Proteins …
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