Background Human immunodeficiency virus (HIV)-related chronic lung disease (CLD)
among children is associated with substantial morbidity, despite antiretroviral therapy. This
may be a consequence of repeated respiratory tract infections and/or dysregulated immune
activation that accompanies HIV infection. Macrolides have anti-inflammatory and
antimicrobial properties, and we hypothesised that azithromycin would reduce decline in
lung function and morbidity through preventing respiratory tract infections and controlling …