Histone acetylation and deacetylation, which are catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively, play important roles in transcriptional regulation.[1] Inhibitors of these enzymes induce cell-cycle arrest,[2] p53-independent induction of the cyclin-dependent kinase inhibitor p21,[3] tumor-selective apoptosis,[4] and differentiation of normal and malignant cells.[5] Recently, HDAC inhibitors such as trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA) were demonstrated to exert potent anti-angiogenic effects through the alteration of vascular endothelial growth factor signaling.[6] These direct and