BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

H Peluffo, U Unzueta, ML Negro-Demontel, Z Xu… - Biotechnology …, 2015 - Elsevier
The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already
available, the Blood Brain Barrier and to a lesser extent, the Blood Spinal Cord Barrier pose
physical and biological limitations to their diffusion to reach target tissues. Therefore, efforts
are needed not only to address drug development but specially to design suitable vehicles
for delivery into the CNS through systemic administration. In the context of the functional and …

[PDF][PDF] BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

C en Bioingeniería, B y Nanomedicina - 2015 - academia.edu
The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already
available, the Blood Brain Barrier and to a lesser extent, the Blood Spinal Cord Barrier pose
physical and biological limitations to their diffusion to reach target tissues. Therefore, efforts
are needed not only to address drug development but specially to design suitable vehicles
for delivery into the CNS through systemic administration. In the context of the functional and …
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