[HTML][HTML] BRCA1 germline mutations may be associated with reduced ovarian reserve
ET Wang, MD Pisarska, C Bresee, YDI Chen, J Lester… - Fertility and sterility, 2014 - Elsevier
Objective To determine whether BRCA carriers have a decreased ovarian reserve
compared with women without BRCA mutations, because BRCA mutations may lead to
accelerated oocyte apoptosis due to accumulation of damaged DNA. Design Cross-
sectional study. Setting Academic tertiary care center. Patient (s) A total of 143 women, aged
18–45 years, who underwent clinical genetic testing for BRCA deleterious mutations
because of a family history of cancer, were included. The cohort was classified into three …
compared with women without BRCA mutations, because BRCA mutations may lead to
accelerated oocyte apoptosis due to accumulation of damaged DNA. Design Cross-
sectional study. Setting Academic tertiary care center. Patient (s) A total of 143 women, aged
18–45 years, who underwent clinical genetic testing for BRCA deleterious mutations
because of a family history of cancer, were included. The cohort was classified into three …
以上显示的是最相近的搜索结果。 查看全部搜索结果