Balancing Selection at HLA-G Modulates Fetal Survival, Preeclampsia and Human Birth Sex Ratio
S Wedenoja, M Yoshihara, H Teder, H Sariola… - BioRxiv, 2019 - biorxiv.org
The population sex ratio is thought to be maintained through balancing selection on rare
phenotypes. However, empirical evidence for genetic influence has thus far proven elusive.
We combined 1000 Genomes data and large cohorts to study human sex ratios. We found
underrepresentation of male offspring in preeclampsia, a serious pregnancy disorder with
uncertain pathogenesis. Genetic variation of fetal human leukocyte antigen G (HLA-G),
regulating maternal anti-fetal immune responses, was found to be under balancing …
phenotypes. However, empirical evidence for genetic influence has thus far proven elusive.
We combined 1000 Genomes data and large cohorts to study human sex ratios. We found
underrepresentation of male offspring in preeclampsia, a serious pregnancy disorder with
uncertain pathogenesis. Genetic variation of fetal human leukocyte antigen G (HLA-G),
regulating maternal anti-fetal immune responses, was found to be under balancing …
Balancing Selection atHLA-GModulates Fetal Survival, Preeclampsia and Human Birth Sex Ratio
S Wedenoja, M Yoshihara, H Teder, H Sariola… - 2019 - europepmc.org
The population sex ratio is thought to be maintained through balancing selection on rare
phenotypes. However, empirical evidence for genetic influence has thus far proven elusive.
We combined 1000 Genomes data and large cohorts to study human sex ratios. We found
underrepresentation of male offspring in preeclampsia, a serious pregnancy disorder with
uncertain pathogenesis. Genetic variation of fetal human leukocyte antigen G (HLA-G),
regulating maternal anti-fetal immune responses, was found to be under balancing …
phenotypes. However, empirical evidence for genetic influence has thus far proven elusive.
We combined 1000 Genomes data and large cohorts to study human sex ratios. We found
underrepresentation of male offspring in preeclampsia, a serious pregnancy disorder with
uncertain pathogenesis. Genetic variation of fetal human leukocyte antigen G (HLA-G),
regulating maternal anti-fetal immune responses, was found to be under balancing …