Bayesian biclustering for patient stratification

S Khakabimamaghani, M Ester - Biocomputing 2016: Proceedings …, 2016 - World Scientific
Biocomputing 2016: Proceedings of the Pacific Symposium, 2016World Scientific
The move from Empirical Medicine towards Personalized Medicine has attracted attention to
Stratified Medicine (SM). Some methods are provided in the literature for patient
stratification, which is the central task of SM, however, there are still significant open issues.
First, it is still unclear if integrating different datatypes will help in detecting disease subtypes
more accurately, and, if not, which datatype (s) are most useful for this task. Second, it is not
clear how we can compare different methods of patient stratification. Third, as most of the …
The move from Empirical Medicine towards Personalized Medicine has attracted attention to Stratified Medicine (SM). Some methods are provided in the literature for patient stratification, which is the central task of SM, however, there are still significant open issues. First, it is still unclear if integrating different datatypes will help in detecting disease subtypes more accurately, and, if not, which datatype(s) are most useful for this task. Second, it is not clear how we can compare different methods of patient stratification. Third, as most of the proposed stratification methods are deterministic, there is a need for investigating the potential benefits of applying probabilistic methods. To address these issues, we introduce a novel integrative Bayesian biclustering method, called B2PS, for patient stratification and propose methods for evaluating the results. Our experimental results demonstrate the superiority of B2PS over a popular state-of-the-art method and the benefits of Bayesian approaches. Our results agree with the intuition that transcriptomic data forms a better basis for patient stratification than genomic data.
World Scientific
以上显示的是最相近的搜索结果。 查看全部搜索结果