Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma
Background Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-
inducible transcription factors that govern various essential metabolic activities in the liver
and other organs. Recently, berberine (BBR) has been characterized as a modulator of
PPARs; however, the matter of whether PPARs are involved in the inhibitory effect of BBR on
hepatocellular carcinoma (HCC) is not well understood. Purpose This study aimed to
investigate the role of PPARs in the suppressive effect of BBR on HCC and to elucidate the …
inducible transcription factors that govern various essential metabolic activities in the liver
and other organs. Recently, berberine (BBR) has been characterized as a modulator of
PPARs; however, the matter of whether PPARs are involved in the inhibitory effect of BBR on
hepatocellular carcinoma (HCC) is not well understood. Purpose This study aimed to
investigate the role of PPARs in the suppressive effect of BBR on HCC and to elucidate the …