Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors
AR Nunes, APS Holmes, V Sample, P Kumar… - Respiratory physiology …, 2013 - Elsevier
Stimulation of the carotid body (CB) chemoreceptors by hypercapnia triggers a reflex
ventilatory response via a cascade of cellular events, which includes generation of cAMP.
However, it is not known if molecular CO 2/HCO 3− and/or H+ mediate this effect and how
these molecules contribute to cAMP production. We previously reported that the CB highly
expresses HCO 3−-sensitive soluble adenylyl cyclase (sAC). In the present study we
systematically characterize the role of sAC in the CB, comparing the effect of isohydric …
ventilatory response via a cascade of cellular events, which includes generation of cAMP.
However, it is not known if molecular CO 2/HCO 3− and/or H+ mediate this effect and how
these molecules contribute to cAMP production. We previously reported that the CB highly
expresses HCO 3−-sensitive soluble adenylyl cyclase (sAC). In the present study we
systematically characterize the role of sAC in the CB, comparing the effect of isohydric …
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