Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
The presynaptic protein α-synuclein has been implicated in the pathogenesis of Parkinson's
disease. First, two missense mutations A30P and A53T cause inheritable early onset
Parkinson's disease in some families. Secondly, α-synuclein is present in Lewy bodies of
affected nerve cells in the predominant sporadic type of Parkinson's disease as well as in
dementia with Lewy bodies. We demonstrate in the rat optic system that a portion of α-
synuclein is carried by the vesicle-moving fast component of axonal transport and that it …
disease. First, two missense mutations A30P and A53T cause inheritable early onset
Parkinson's disease in some families. Secondly, α-synuclein is present in Lewy bodies of
affected nerve cells in the predominant sporadic type of Parkinson's disease as well as in
dementia with Lewy bodies. We demonstrate in the rat optic system that a portion of α-
synuclein is carried by the vesicle-moving fast component of axonal transport and that it …
以上显示的是最相近的搜索结果。 查看全部搜索结果