Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: a randomized phase II trial
H Orlent, BE Hansen, M Willems, JT Brouwer… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: Phase I/II studies of 4 weeks duration have confirmed the ALT
lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to
determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond
4 weeks and evaluate its effect on liver histology and quality of life. METHODS: HCV-RNA-
positive patients with elevated ALT and marked fibrosis or necro-inflammation who were not
eligible for interferon therapy were treated for 4 weeks with six infusions weekly of …
lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to
determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond
4 weeks and evaluate its effect on liver histology and quality of life. METHODS: HCV-RNA-
positive patients with elevated ALT and marked fibrosis or necro-inflammation who were not
eligible for interferon therapy were treated for 4 weeks with six infusions weekly of …
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