Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy

TA Tabish, CJ Scotton, DC J Ferguson, L Lin… - …, 2018 - Taylor & Francis
TA Tabish, CJ Scotton, DC J Ferguson, L Lin, A der Veen, S Lowry, M Ali, F Jabeen, M Ali…
Nanomedicine, 2018Taylor & Francis
Aim: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic
therapy (PDT) remains challenging. Graphene quantum dots (GQDs) hold great promise for
PDT. However, the photochemical processes leading to GQD-derived ROS generation have
not yet been fully elucidated. Materials & methods: Physicochemical characteristics of GQDs
were comprehensively investigated, including electron paramagnetic resonance analysis of
singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. Results: GQDs …
Aim
Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQDs) hold great promise for PDT. However, the photochemical processes leading to GQD-derived ROS generation have not yet been fully elucidated.
Materials & methods
Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo.
Results
GQDs demonstrated excellent photoluminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet oxygen/ROS generation.
Conclusion
The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application.
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