Biodegradable hyperbranched polyglycerols (dHPGs) were synthesized through oxyanionic
initiating hybrid polymerization of glycerol and glycidyl methacrylate. Due to the introduction
of ester linkages into the hyperbranched polyglycerol backbone, dHPGs showed good
biodegradability and low cytotoxicity. Benefiting from the existence of terminal hydroxyls and
methacryloyl groups, both the anticancer drug methotrexate (MTX) and fluorescent probe
Rhodamine-123 could be conjugated onto the surface of dHPGs easily. The resultant MTX …