Bioengineered 2′-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory …
S Weichert, S Jennewein, E Hüfner, C Weiss… - Nutrition research, 2013 - Elsevier
Human milk oligosaccharides help to prevent infectious diseases in breastfed infants. Larger
scale testing, particularly in animal models and human clinical studies, is still limited due to
shortened availability of more complex oligosaccharides. The purpose of this study was to
evaluate 2′-fucosyllactose (2′-FL) and 3-fucosyllactose (3-FL) synthesized by whole-cell
biocatalysis for their biological activity in vitro. Therefore, we have tested these
oligosaccharides for their inhibitory potential of pathogen adhesion in two different human …
scale testing, particularly in animal models and human clinical studies, is still limited due to
shortened availability of more complex oligosaccharides. The purpose of this study was to
evaluate 2′-fucosyllactose (2′-FL) and 3-fucosyllactose (3-FL) synthesized by whole-cell
biocatalysis for their biological activity in vitro. Therefore, we have tested these
oligosaccharides for their inhibitory potential of pathogen adhesion in two different human …
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