The persistently high incidence of knee ligament injuries has spurred a growing interest in
the biology of ligament healing. Similarly, the recognition that healed ligament tissue is
structurally inferior to the intact ligament has focused efforts on potential biologic
interventions aimed at improving the quality of healed tissue. A host of in vitro and in vivo
studies have recently begun to elucidate the role of several growth factors in regulating
ligament healing in structures such as the medial collateral ligament. Evidence that growth …