Biosynthesis and fate of endocannabinoids

MG Cascio, P Marini - Endocannabinoids, 2015 - Springer
… and metabolic routes of the n-6 endocannabinoids is not yet clear and so warrants further …
primary biosynthetic and metabolic pathways for the two well-established endocannabinoids, …

Metabolic fate of endocannabinoids

VD Marzo - Current Neuropharmacology, 2004 - ingentaconnect.com
… into their endocannabinoid products. The biosynthesis of endocannabinoids is immediately
… , there cannot be enhanced endocannabinoid release outside the cell without enhanced …

The biosynthesis, fate and pharmacological properties of endocannabinoids

V Di Marzo, T Bisogno, L De Petrocellis - Cannabinoids, 2005 - Springer
endocannabinoids. This in turn meant that the enzymes catalysing endocannabinoid biosynthesis
… as (1) probes to confirm endocannabinoid involvement in health and disease, and (2) …

Endogenous cannabinoids revisited: a biochemistry perspective

BM Fonseca, MA Costa, M Almada… - Prostaglandins & other …, 2013 - Elsevier
endocannabinoid family is larger than initially thought but also expand our view on the possible
molecular mechanisms for the biosynthesis, … However, recent data identify a new fate for …

Endocannabinoid transport revisited

S Nicolussi, J Gertsch - Vitamins & Hormones, 2015 - Elsevier
biosynthesis and metabolism have been studied in detail, it remains unclear how
endocannabinoids … Interestingly, the fate of ethanolamine generated by AEA hydrolysis can be …

Basic mechanisms of synthesis and hydrolysis of major endocannabinoids

N Battista, M Maccarrone - The Endocannabinoid System, 2017 - Elsevier
… that, together with their molecular targets, biosynthetic and catabolic enzymes, form the so-called
endocannabinoid system.” Despite the … Biosynthesis and fate of endocannabinoids

Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2‐arachidonoyl‐glycerol and its congeners in human …

C Turcotte, AS Archambault, E Dumais… - The FASEB …, 2020 - Wiley Online Library
… To better mimic their fate, adenosine deaminase (0.3 U/mL) was added 10 minutes … AA-induced
2-AG biosynthesis and the EPA-induced 2-EPG biosynthesis is likely the consequence …

[HTML][HTML] New insights into peptide cannabinoids: structure, biosynthesis and signaling

A Riquelme-Sandoval, CO de Sá-Ferreira… - Frontiers in …, 2020 - frontiersin.org
… evidence on lipid endocannabinoids, cannabinoid receptors … the pharmacological effects,
the biosynthesis of the peptide … metabolism, cell survival, cell fate and apoptosis. They activate …

Oxidative metabolism of endocannabinoids

KR Kozak, LJ Marnett - … , Leukotrienes and Essential Fatty Acids (PLEFA), 2002 - Elsevier
… a range of agonists, and accounts for PG biosynthesis in inflammatory cells and, in large part,
… that similar balances will dictate the metabolic fate of endocannabinoids in other cell types. …

Early phytocannabinoid chemistry to endocannabinoids and beyond

R Mechoulam, LO Hanuš, R Pertwee… - Nature Reviews …, 2014 - nature.com
endocannabinoids are synthesized 'on demand' rather than stored, and it identified biosynthetic
… and extracellular actions and fate of endocannabinoids versus those of exogenously …