Bismuth-catalyzed stereoselective 2-deoxyglycosylation of disarmed/armed glycal donors
Bi (OTf) 3 promoted direct and highly stereoselective glycosylation of “disarmed” and
“armed” glycals to synthesize 2-deoxyglycosides has been reported. The tunable and
solvent-controlled chemoselective activation of deactivated glycal donors distinguishing the
competitive Ferrier and 1, 2-addition pathways was discovered to improve substrate scope.
The practical versatility of the method has been amply demonstrated with the
oligosaccharide syntheses and 2-deoxyglycosylation of high-value natural products and …
“armed” glycals to synthesize 2-deoxyglycosides has been reported. The tunable and
solvent-controlled chemoselective activation of deactivated glycal donors distinguishing the
competitive Ferrier and 1, 2-addition pathways was discovered to improve substrate scope.
The practical versatility of the method has been amply demonstrated with the
oligosaccharide syntheses and 2-deoxyglycosylation of high-value natural products and …
Bi(OTf)3 promoted direct and highly stereoselective glycosylation of “disarmed” and “armed” glycals to synthesize 2-deoxyglycosides has been reported. The tunable and solvent-controlled chemoselective activation of deactivated glycal donors distinguishing the competitive Ferrier and 1,2-addition pathways was discovered to improve substrate scope. The practical versatility of the method has been amply demonstrated with the oligosaccharide syntheses and 2-deoxyglycosylation of high-value natural products and drugs.
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