Context Second cancer is the leading cause of death in long-term survivors of Hodgkin
disease (HD), with exceptionally high risks of breast cancer among women treated at a
young age. Quantitative associations between radiotherapy dose delivered to the breast and
administered chemotherapy have not been reported to date in large series, nor has the
influence of ovarian exposures on subsequent risk. Objective To quantify the long-term risk
of breast cancer associated with use of radiotherapy and chemotherapy to treat young …