Butyrate-Induced In Vitro Colonocyte Differentiation Network Model Identifies ITGB1, SYK, CDKN2A, CHAF1A, and LRP1 as the Prognostic Markers for Colorectal …
Numerous mechanisms are believed to contribute to the role of dietary fiber-derived butyrate
in the protection against the development of colorectal cancers (CRCs). To identify the most
crucial butyrate-regulated genes, we exploited whole genome microarray of HT-29 cells
differentiated in vitro by butyrate treatment. Butyrate differentiates HT-29 cells by relaxing the
perturbation, caused by mutations of Adenomatous polyposis coli (APC) and TP53 genes,
the most frequent mutations observed in CRC. We constructed protein–protein interaction …
in the protection against the development of colorectal cancers (CRCs). To identify the most
crucial butyrate-regulated genes, we exploited whole genome microarray of HT-29 cells
differentiated in vitro by butyrate treatment. Butyrate differentiates HT-29 cells by relaxing the
perturbation, caused by mutations of Adenomatous polyposis coli (APC) and TP53 genes,
the most frequent mutations observed in CRC. We constructed protein–protein interaction …
Butyrate-induced in vitro colonocyte differentiation network model identifies ITGB1, SYK, CDKN2A, CHAF1a, and LRP1 as the prognostic markers for colorectal …
ND Nirmalya Dasgupta, BK Thakur… - 2019 - cabidigitallibrary.org
Numerous mechanisms are believed to contribute to the role of dietary fiber-derived butyrate
in the protection against the development of colorectal cancers (CRCs). To identify the most
crucial butyrate-regulated genes, we exploited whole genome microarray of HT-29 cells
differentiated in vitro by butyrate treatment. Butyrate differentiates HT-29 cells by relaxing the
perturbation, caused by mutations of Adenomatous polyposis coli (APC) and TP53 genes,
the most frequent mutations observed in CRC. We constructed protein-protein interaction …
in the protection against the development of colorectal cancers (CRCs). To identify the most
crucial butyrate-regulated genes, we exploited whole genome microarray of HT-29 cells
differentiated in vitro by butyrate treatment. Butyrate differentiates HT-29 cells by relaxing the
perturbation, caused by mutations of Adenomatous polyposis coli (APC) and TP53 genes,
the most frequent mutations observed in CRC. We constructed protein-protein interaction …
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