We review the contribution made by CD8+ T cells to inflammation in the central nervous
system (CNS) in Multiple Sclerosis (MS), and discuss their role in the animal model
Experimental Autoimmune Encephalomyelitis (EAE). We show that the inflammatory
cytokines interferon-gamma and interleukin-17 are differentially regulated in CNS-infiltrating
CD4+ and CD8+ T cells in EAE, and that CD8+ T cells regulate disease. In MS, CD8+ T cells
appear to play a role in promotion of disease, so cytokine regulation is likely different in …