… Erenumab and CGRP antagonists as a whole significantly … CGRP antagonists appear to
significantly improve treatment … Erenumab is the first CGRP antagonist to be FDA approved for …

… gene-related peptide (CGRP). BIBN4096 was the first CGRP antagonist to be tested in …
The proven efficacy of this agent, and also the CGRP antagonist MK-0974, to alleviate acute …

… CGRP receptor antagonists, the importance of CGRP in the pathophysiology of migraine and
the therapeutic principle of CGRP … The present review will discuss the role of CGRP in the …

… release and pain in migraine headache, which points toward the potential usefulness of
a specific CGRP antagonist in the treatment of primary headaches. The demonstration that …

… peptide (CGRP) receptor antagonistic molecules have … Drugs from the gepant class of
CGRP receptor antagonists are … As an alternative approach to block CGRP transmission, fully …

… useful studies using labeled CGRP antagonists, such as MK-3207 and MK-4232.73, 74
Although these antagonists are only weakly selective between CGRP and AMY 1 receptors (∼30…

… Together with the fact that the CGRP antagonists olcegepant … of CGRP antagonists in the
acute treatment of migraine. The lack of sensitization of meningeal nociceptors by topical CGRP …

… However, the remaining issue is to understand the site of action of the CGRP-receptor
antagonists. There are three potential targets: the intracranial blood vessels, parts of the trigeminal …

… CGRP receptor antagonists, including olcegepant (BIBN4096BS) and … these antagonists
at blocking CGRP receptor signalling in trigeminal ganglia (TG) neurons and transfected CGRP …

… for selective binding of CGRP, olcegepant functions as a CGRP receptor antagonist by
directly … ligand CGRP and, therefore, inhibits the physiological and cellular effects of CGRP. …