… animal models of migraine involve CGRP to some degree. The importance of CGRP in
those models is confirmed by the ability of direct injection of CGRP to induce several migraine-…

… animal model of migraine induced by epidural injection of calcitonin gene-related peptide
(CGRP), … to establish a new animal model of migraine through epidural injection of CGRP. The …

… NTG-induced trigeminal hyperalgesia, we first tested two doses of the CGRP receptor
antagonist in the acute animal model of migraine on the basis of a single NTG (10 mg/kg, ip) …

… brainstem as a key regulator of migraine biology and associated symptoms. We … CGRP in
the brainstem and its modulation for migraine therapy, given the emergence of targeted CGRP …

… migraine. However, a major challenge for studying CGRP actions is the lack of animal models
for migraine. … are more sensitive to CGRP than people who do not suffer from migraine. We …

… A validated animal model could help to decipher the pathogenic mechanism of the disease,
… aimed to summarize current animal models of CM and discuss the validity of these models. …

… targeted to calcitonin-gene-related peptide (CGRP) and its … For CGRP, potential cardiac
liability issues have recently … Burden of Disease Study 2015 lists migraine at number five as a …

… that the CGRP pathway is crucial in migraine pathophysiology [45], it may be that simple
perturbation of meningeal and trigeminovascular nociceptors is sufficient to model migraine and …

… animal models with ability to predict efficacy of anti-migraine … of CGRP and blocked by
co-administration of the CGRP … if migraine triggering substances other than CGRP are able …

… Animal models of migraine focused on trigeminal sensory processing have increased our
mechanistic understanding of migraine … of inhibiting CGRP signaling [8], the use of CGRP …