The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct
(CCD) is highlighted by various water and electrolyte disorders that arise when the unique
transport properties of these segments are disturbed. Despite this critical role, little is known
about which proteins have a regulatory role in these cells and how these cells can be
regulated by individual physiologic stimuli. By combining proteomics, bioinformatics, and
cell biology approaches, we found that the E3 ubiquitin ligase CHIP is highly expressed …