CI-1011 lowers lipoprotein (a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeys
R Ramharack, MA Spahr, CS Sekerke, RL Stanfield… - Atherosclerosis, 1998 - Elsevier
Lipoprotein (a)(Lp (a)), which is generated through the covalent association of
apolipoprotein (a)(apo (a)) and apo B-100-LDL, is an independent risk factor for several
vascular diseases. Therefore, there is interest in developing therapies for lowering Lp (a).
This investigation was carried out to determine the effect of CI-1011, a potent lipid regulator
in rodents, on Lp (a) and other lipid parameters in cynomolgus monkeys (Macaca
fascicularis). Nine healthy male monkeys on a normal chow diet were orally treated with CI …
apolipoprotein (a)(apo (a)) and apo B-100-LDL, is an independent risk factor for several
vascular diseases. Therefore, there is interest in developing therapies for lowering Lp (a).
This investigation was carried out to determine the effect of CI-1011, a potent lipid regulator
in rodents, on Lp (a) and other lipid parameters in cynomolgus monkeys (Macaca
fascicularis). Nine healthy male monkeys on a normal chow diet were orally treated with CI …
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