CT fractional flow reserve (FFR_CT) is a physiologic simulation technique that models coronary flow from routine coronary CT angiography (CTA). To evaluate lesion-specific ischemia, FFR_CT is measured 2 cm distal to a stenotic lesion. FFR_CT greater than 0.8 is normal, 0.76–0.8 is borderline, and 0.75 or less is abnormal. FFR_CT should always be interpreted in correlation with clinical and anatomic coronary CTA findings. FFR_CT increases the specificity of coronary CTA in the evaluation of coronary artery disease, decreases the prevalence of nonobstructive disease in invasive coronary angiography (ICA), and helps with revascularization decisions and planning. Patients with intermediate-risk coronary anatomy at CTA and abnormal FFR_CT can undergo ICA and revascularization, whereas those with normal FFR_CT can be safely deferred from ICA. In borderline FFR_CT values, management is decided in the context of the clinical scenario, but many cases could be safely managed with medical treatment. There are some limitations and pitfalls of FFR_CT. Abnormal FFR_CT values can be seen in mild stenosis, and normal FFR_CTvalues can be seen in severe stenosis. Gradually decreasing or abnormal low FFR_CT values at the distal vessel without a proximal focal lesion could be due to diffuse atherosclerosis. Coronary stents, bypass grafts, coronary anomalies, coronary dissection, transcatheter aortic valve replacement, unstable angina, and acute or recent myocardial infarction are situations in which FFR_CT has not been validated and should not be used at this time. The authors provide a practical guide to the applications and interpretation of FFR_CT, focusing on common pitfalls and challenges.

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