Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers.

F Rodriguez de Fonseca, AJ Roberts… - Zhongguo yao li xue …, 1999 - europepmc.org
F Rodriguez de Fonseca, AJ Roberts, A Bilbao, GF Koob, M Navarro
Zhongguo yao li xue bao= Acta pharmacologica Sinica, 1999•europepmc.org
Aim To study the potential role of dependence status on CB1-mediated blockade of ethanol
self-administration. Methods We examined the effects of the cannabinoid antagonist
SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in
male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol
vapor-chambers or exposed to air in identical vapor chambers. Results Dependent animals
responded more for ethanol than did air control nondependent rats. The acute …
Aim
To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration.
Methods
We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers.
Results
Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A.
Conclusion
These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism.
europepmc.org
展开收起
被引用次数：121 相关文章 所有 2 个版本
以上显示的是最相近的搜索结果。 查看全部搜索结果