Capsule promotes intracellular survival and vascular endothelial cell translocation during invasive pneumococcal disease
The polysaccharide capsule that surrounds Streptococcus pneumoniae (Spn) is one of its
most important virulence determinants, serving to protect against phagocytosis. To date, 100
biochemical and antigenically distinct capsule types, ie, serotypes, of Spn have been
identified. Yet how capsule influences pneumococcal translocation across vascular
endothelial cells (VEC), a key step in the progression of invasive disease, was unknown.
Here, we show that despite capsule being inhibitory of Spn uptake by VEC, capsule …
most important virulence determinants, serving to protect against phagocytosis. To date, 100
biochemical and antigenically distinct capsule types, ie, serotypes, of Spn have been
identified. Yet how capsule influences pneumococcal translocation across vascular
endothelial cells (VEC), a key step in the progression of invasive disease, was unknown.
Here, we show that despite capsule being inhibitory of Spn uptake by VEC, capsule …
[引用][C] Capsule promotes intracellular survival and vascular endothelial cell translocation during invasive pneumococcal disease. mBio. 12: e0251621
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