Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism
YQ Song, Q Jin, DD Wang, J Hou, LW Zou… - Chemico-Biological …, 2021 - Elsevier
Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide
bond (s). In humans, most of identified CES are segregated into the CES1A and CES2A
subfamilies. Strong inhibition on human CES (including hCES1A and hCES2A) may
modulate pharmacokinetic profiles of CES-substrate drugs, thereby changing the
pharmacological and toxicological responses of these drugs. This review covered recent …
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide
bond (s). In humans, most of identified CES are segregated into the CES1A and CES2A
subfamilies. Strong inhibition on human CES (including hCES1A and hCES2A) may
modulate pharmacokinetic profiles of CES-substrate drugs, thereby changing the
pharmacological and toxicological responses of these drugs. This review covered recent …
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