Cardiac connexins: genes to nexus

HS Duffy, AG Fort, DC Spray - Cardiovascular Gap Junctions, 2006 - karger.com
… Contributions of each of these connexins to heart function has been in many cases illuminated
by connexin null mice. The cardiac connexin genes whose genomic organization and …

The cardiac mitochondrion: nexus of stress

CP Baines - Annual review of physiology, 2010 - annualreviews.org
… channels and connexin-43 have now been implicated as critical regulators of cardiac cell
death. … that cardiac-specific excision of the Nix gene could block pressure overload–induced …

Gap-junction proteins in retinal development: new roles for the “nexus

JE Cook, DL Becker - Physiology, 2009 - journals.physiology.org
… one connexin gene may act as a central focus or hub for such a network, taking the nexus
… have mitochondria-related functions in tissues other than cardiac muscle remains an open …

Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression

N Sultana, K Nag, K Hoshijima… - Proceedings of the …, 2008 - National Acad Sciences
… of the responsible genes in CHD, is severely down-regulated in the ftk heart that exhibits …
allele of the connexin gene cx36.7/early cardiac connexin (ecx), expressed during early heart

Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets

K Andelova, T Egan Benova… - International Journal of …, 2020 - mdpi.com
… The over-expression of microRNA-1 results in the post-transcriptional repression of GJA1
genes … In addition, they also act at the peri-nexus [22], ie, at the peri-gap junctional membrane (…

Regulation of connexins genes expression contributes to reestablishes tissue homeostasis in a renovascular hypertension model

ALT Enes, C Vicente, JV Grégio, CG Clecêncio… - Heliyon, 2020 - cell.com
cardiac response were regulated transcriptionally by renovascular hypertension 2K1C.
Moreover, the results of connexin gene … a relationship between cardiac and renal physiological …

Cardiac cell–cell junctions in health and disease: electrical versus mechanical coupling

M Noorman, MAG van der Heyden… - … and cellular cardiology, 2009 - Elsevier
… A connexon docks to another connexon in the intercellular space to create a complete GJ …
no genetic modifications have been made to induce heart failure the effects of heart failure on …

[HTML][HTML] The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target

DT Hoagland, W Santos, S Poelzing… - Progress in biophysics …, 2019 - Elsevier
… of connexin proteins expressed by mammalian myocardial … There are numerous mutations
in the gene encoding the α-… The nexus is an alternative name for the GJ, thus the peripheral …

Role of connexins and pannexins in cardiovascular physiology

MJ Meens, BR Kwak, HS Duffy - Cellular and molecular life sciences, 2015 - Springer
… For that reason, a vast number of studies have addressed the role of connexins and pannexins
in the arterial and venous systems as well as in the heart. Moreover, a role for connexins

Cardiac connexins and impulse propagation

JA Jansen, TAB van Veen, JMT de Bakker… - … and cellular cardiology, 2010 - Elsevier
… However, because most cardiac connexins are expressed in multiple cell types in the heart,
we will follow the cardiac impulse on its path through the … Cardiac connexins: genes to nexus