The purpose of the current sequential, explanatory mixed-methods study was to identify and explain differences in levels of caregiver burnout, job satisfaction, and the perceived quality of care provided by nurses working in palliative care and non-palliative care inpatient units at a Florida, Veterans Affairs hospital. A mixed-methods design was used to address the research problem adequately. First, quantitative data were collected using Maslach Burnout Inventory–Human Services Survey and Job Satisfaction Survey instruments. Second, qualitative data were gathered through face-to-face interviews. The population included 157 Licensed Practical Nurses, Registered Nurses and Nurse Managers for the quantitative portion of the study, and 9 Nurse Managers for the qualitative portion. The response rate for each portion of this study was 50%. Quantitative data were analyzed using one-tailed independent samples t test to compare mean scores of burnout and job satisfaction among nurses providing care in the two types of inpatient units. The results were non-significant supporting the null hypothesis of no difference between the groups; however, they did show relationships between years of experience and burnout (negative association) and job satisfaction (positive association). Qualitative data were analyzed using the constant comparative, content analysis method. Perceptions of the nurse managers were revealed through emerging themes and categories. The main categories were support services, time, care provided, and compassion. Firsthand knowledge provided helpful information for leadership that could decrease caregiver burnout and increase job satisfaction, improve the quality of patient care for veterans, increase nursing staff retention, and enhance the work environment.