Castleman's disease (giant lymph node hyperplasia, angiofollicular hyperplasia, lymphoid
hamartoma, benign giant lymphoma), is a quite rare and complex disease of lymphoid tissue
that causes progressive lymph node enlargement, typically presenting as a solitary
mediastinal mass. It was first described by Castleman et al in 1956. The head and neck
regions are the second, less common site for this lesion. The preoperative diagnosis is very
often extremely difficult and the routine investigations are often inconclusive. A multicentric …

Castleman disease (CD) is a rare benign lymphoproliferative disorder of unknown etiology,
typically presenting as a solitary mediastinal mass. The head and neck region is the most
common site; however, the salivary glands are rarely affected. We present a rare case of a
59-year-old male patient with mixed type CD localized in the parotid gland. The patient
underwent a left superficial parotidectomy with a clinical prediagnosis of mucoepidermoid
carcinoma. H&E stained sections showed mostly preserved lymph node architecture. Some …