Multiple endocrine neoplasia type 1 (MEN1) is classically characterized by the development
of functional or nonfunctional hyperplasia or tumors in endocrine tissues (parathyroid,
pancreas, pituitary, adrenal). Because effective treatments have been developed for the
hormone excess state, which was a major cause of death in these patients in the past,
coupled with the recognition that nonendocrine tumors increasingly develop late in the
disease course, the natural history of the disease has changed. An understanding of the …