CD22, AB LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING*
TF Tedder, J Tuscano, S Sato… - Annual review of …, 1997 - annualreviews.org
▪ Abstract The development of B lymphocytes is a highly regulated process that depends in
part on lineage-specific cell surface molecules. In addition, transmembrane signals
generated through the B cell antigen receptor and other surface molecules regulate B cell
responses to foreign antigens. Recent studies reveal CD22 to be a functionally significant
receptor during these processes. CD22 is first expressed in the cytoplasm of pro-B and pre-
B cells, and on the surface as B cells mature to become IgD+. CD22 is a member of the Ig …
part on lineage-specific cell surface molecules. In addition, transmembrane signals
generated through the B cell antigen receptor and other surface molecules regulate B cell
responses to foreign antigens. Recent studies reveal CD22 to be a functionally significant
receptor during these processes. CD22 is first expressed in the cytoplasm of pro-B and pre-
B cells, and on the surface as B cells mature to become IgD+. CD22 is a member of the Ig …
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