Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
T Shirai, A Nakai, E Ando, J Fujimoto, S Leach… - Science …, 2023 - science.org
Celastrol, a bioactive molecule extracted from the Tripterygium wilfordii plant, has been
shown to exhibit anti-inflammatory properties. However, its mechanism of action has not
been fully elucidated. Here, we show that celastrol suppresses humoral immune responses
and autoimmunity by disabling a protein complex consisting of copper metabolism MURR1
domain–containing (COMMD) 3 and COMMD8 (COMMD3/8 complex), a signaling adaptor
for chemoattractant receptors. Having demonstrated the involvement of the COMMD3/8 …
shown to exhibit anti-inflammatory properties. However, its mechanism of action has not
been fully elucidated. Here, we show that celastrol suppresses humoral immune responses
and autoimmunity by disabling a protein complex consisting of copper metabolism MURR1
domain–containing (COMMD) 3 and COMMD8 (COMMD3/8 complex), a signaling adaptor
for chemoattractant receptors. Having demonstrated the involvement of the COMMD3/8 …
Celastrol suppresses humoral immune responses
白井太一朗 - 2023 - ir.library.osaka-u.ac.jp
… Title Celastrol suppresses humoral immune responses and autoimmunity by targeting
the COMMD3/8 complex …
the COMMD3/8 complex …
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