Recently, there has been an explosion in the number of in vivo studies using genetically
engineered mouse models. Atherosclerosis research using mice began with the invention of
traditional atherosclerotic mice including low-density lipoprotein receptor knockout
(LDLR−/−) and apolipoprotein E knockout (apoE−/−) mice, which provided tremendous
progress in atherosclerosis research. Since then, a number of modified atherosclerotic
mouse models have been reported to generate lesions that more closely characterize …