Pyocyanin has recently emerged as an important virulence factor produced by
Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a
number of potential effects on various organ systems in vitro, including the respiratory,
cardiovascular, urological, and central nervous systems. It has been shown that a large
number of the effects to these systems are via the formation of reactive oxygen species. The
limitations of studies are, to date, focused on the localized effect of the release of pyocyanin …