Central IRF4/5 signaling are critical for microglial activation and impact on stroke outcomes
Microglia and monocytes play a critical role in immune responses to cerebral ischemia.
Previous studies have demonstrated that interferon regulatory factor 4 (IRF4) and IRF5 direct
microglial polarization after stroke and impact outcomes. However, IRF4/5 are expressed by
both microglia and monocytes, and it is not clear if it is the microglial (central) or monocytic
(peripheral) IRF4-IRF5 regulatory axis that functions in stroke. In this work, young (8–12
weeks) male pep boy (PB), IRF4 or IRF5 flox, and IRF4 or IRF5 conditional knockout (CKO) …
Previous studies have demonstrated that interferon regulatory factor 4 (IRF4) and IRF5 direct
microglial polarization after stroke and impact outcomes. However, IRF4/5 are expressed by
both microglia and monocytes, and it is not clear if it is the microglial (central) or monocytic
(peripheral) IRF4-IRF5 regulatory axis that functions in stroke. In this work, young (8–12
weeks) male pep boy (PB), IRF4 or IRF5 flox, and IRF4 or IRF5 conditional knockout (CKO) …
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