Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various
adenosine receptors have increased our understanding of the functioning of central
adenosine A2A receptors. The A2A receptor is one of four adenosine receptors found in the
brain. Its expression is highest in striatum, nucleus accumbens and olfactory tubercles,
although it also occurs in neurons and microglia in most other brain regions. The receptor …