[引用][C] Central and peripheral GLP-1 systems independently suppress eating. Nat Metab 3: 258–273
DI Brierley, MK Holt, A Singh, A de Araujo, M McDougle… - 2021
Central and peripheral GLP-1 systems independently suppress eating
The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut
enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define
the peripheral and central GLP-1 systems. PPG neurons in the nucleus tractus solitarii (NTS)
are widely assumed to link the peripheral and central GLP-1 systems in a unified gut–brain
satiation circuit. However, direct evidence for this hypothesis is lacking, and the necessary
circuitry remains to be demonstrated. Here we show that PPGNTS neurons encode satiation …
enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define
the peripheral and central GLP-1 systems. PPG neurons in the nucleus tractus solitarii (NTS)
are widely assumed to link the peripheral and central GLP-1 systems in a unified gut–brain
satiation circuit. However, direct evidence for this hypothesis is lacking, and the necessary
circuitry remains to be demonstrated. Here we show that PPGNTS neurons encode satiation …
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